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NOW Cascara Sagrada, 450mg, 100 Capsules Low Carb Vegetarian Protein EPA-heavy formulas (like 2:1 orNOW Cascara Sagrada Details Natural Herbal Laxative A Dietary Supplement Promotes Bowel Function* Cascara sagrada is a natural laxative made from the reddish brown bark of a tree (Rhamnus purshiana) native to the Pacific Northwest.* It was used by various Native American tribes, who also passed their "sacred bark" on to Spanish explorers (cascara sagrada means sacred bark in Spanish). It was not formally used in western medicine until 1877, when the